Immunologie / DELALOY Céline

Study signal integration and B cell responses to external cues that direct plasma cell differentiation, as well as the reprogramming of B cells toward immunosuppressive functions in inflammatory contexts. Development of experimental models and single-cell approaches to decipher normal and tumor B cell plasticity and in vitro differentiation models of human primary B cells to explore the role of key signaling pathways and transcription factors in maintaining B cell homeostasis, as well as their deregulation in autoimmune diseases and cancer. Mechanisms of B cell reprogramming using therapeutic approaches including immunonutrition in sepsis, low-dose IL-2 treatment and mesenchymal stromal cells infusion in autoimmunity.