The Institut Pasteur de Lille, a Center of Excellence in Biology and Biomedical Research, is looking for an outstanding junior and/or senior principal investigator to develop an ambitious project on infectious diseases and/or antimicrobial resistance, as part of a project called CPER- ResIsT-omics «Resistance, Complications, Vulnerability Factors and a Holistic Approach for Therapeutic Innovations in Inflammatory and Infectious Diseases ».
Le projet ANR ANTARBioTic "Deciphering the mechanisms of action of the salt-insensitive king penguin defensins to fulfill the Global One Health Needs" se concentre sur la détermination du mécanisme d'action d'un peptide antimicrobien riche en ponts disulfure extrêmement prometteur, provenant du Manchot Royal. Dans ce projet, nous développons deux techniques biophysiques pour travailler avec des bactéries vivantes : la spectroscopie de fluorescence en temps réel (1) et la RMN à l'état solide (2). Le Dr. Céline Landon a apporté à Orléans une toute nouvelle expérience de spectroscopie de fluorescence en temps réel in vivo (sur bactéries vivantes), tandis que le DR. Dror Warschawski (à Sorbonne Université) a étendu l'approche RMN du deutérium à l'état solide à l'étude des cellules vivantes.
Our team is interested in the intracellular metabolism of pathogenic mycobacteria and in particular the role and degradation of intracytoplasmic lipid inclusions (ILIs) formed during the infection process. The aim of this project, funded from januray 1st, 2025 to December 31st, 2027 by the Agence Nationale de la Recherche, will focus on the identification of proteins involved in the degradation of these ILIs using APEX2 technology.
A post-doctoral position is open at INSERM UMR 976 – HIPI – for 1.5 year with the possibility for a successful candidate of a 1.5 year extension.
The project aims at the development of novel Chimeric Antigen Receptor based therapy targeting Multiple Myeloma tumor plasma cells. The candidate will join a group of 6 persons working on this program and will interact with the clinical departments involved in CAR-T clinical trials.
Mosquitoes transmit life-threatening pathogens, including flaviviruses, such as Dengue, West Nile, and Yellow Fever (YF) viruses. Global warming and trade, as well as increased population mobility broaden the range of mosquitoes' habitat, and increase the density and diversity of competent vectors and thus favoring flaviviruses outbreaks, and increasing the risk of flavivirus associated-pandemics.
The post-doctoral project aims to (1) develop a relevant preclinical model of YF virus transmission; (2) characterize the dynamic of replication and disease in comparison to the subcutaneous injection of YF virus; and (3) evaluate the immunogenicity and protective efficacy of a pan-flavivirus vaccine candidate developed as part of the Flavivaccine HORIZON-HLTH-2023-DISEASE03-18 program (https://flavivaccine.eu/) and decipher its mode of action.
Les chaires juniors permettront à de jeunes scientifiques d’ouvrir et de diriger une équipe de recherche au sein d'un laboratoire établi en France et de développer des projets d'excellence sur le microbiome et la santé.
L'expertise de recherche des candidats devra couvrir au moins une des priorités/axes de recherche du Programme « SAMS ».